distro: Debian Unstable
kernels tested with: 2.6.13-rc3, 2.6.13-rc3-git5, 2.6.13-rc3-mm1
compiler used: Debian gcc-4.0.1-2
Xorg: Debian xorg-6.8.2-4
ASUS P4C800 Deluxe BIOS: 1019 (2005-11-08)

with or wihout ACPI enabled (acpi=off or not) the /dev/input/mice USB
mouse freezes after not being used for some time and can only be
awakened by switching to the text-console and back.

attached you can find all .configs, dmesg from 2.6.13-rc3-git5 and the
xorg.conf.